New podcast episode on Decoding Longevity

July 24, 2025

2025 · podcast

I recently joined Macsue Jacques (Monash University) and Raghav Sehgal (Yale University) for their inspiring podcast, Decoding Longevity, to talk about the translation of ageing biomarkers.

➡️ 🎧 You can listen on Spotify or find out more on LinkedIn.

References

2024

Challenges and recommendations for the translation of biomarkers of aging

Chiara Herzog*, Ludger J E Goeminne*, Jesse R Poganik*, and 31 more authors

Nature Aging, 2024

Abs HTML

Biomarkers of aging (BOA) are quantitative parameters that predict biological age and ideally its changes in response to interventions. In recent years, many promising molecular and omic BOA have emerged with an enormous potential for translational geroscience and improving healthspan. However, clinical translation remains limited, in part due to the gap between preclinical research and the application of BOA in clinical research and other translational settings. We surveyed experts in these areas to better understand current challenges for the translation of aging biomarkers. We identified six key barriers to clinical translation and developed guidance for the field to overcome them. Core recommendations include linking BOA to clinically actionable insights, improving affordability and availability to broad populations and validation of biomarkers that are robust and responsive at the level of individuals. Our work provides key insights and practical recommendations to overcome barriers impeding clinical translation of BOA. Biomarkers of aging have potential to accelerate the clinical translation of interventions that promote healthy aging but are currently limited to research. The authors identify six barriers to be overcome to enable biomarker translation, providing a roadmap to clinical implementation.

Other news

Three new first-author papers. One clear message. 🧬

Presenting a keynote at Longevity Summit Dublin 2025 🇮🇪

Foresight Vision Weekend Puerto Rico 🇵🇷

Honoured to Receive the Professor Anthony Mellows Medal 🏅

2024 Biomarkers of Aging Conference was a success