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New paper on epigenetic host changes induced by HPV

February 23, 2023

2023   ·   exposures   hpv   cervical-cancer     ·   papers  

Our new paper on epigenetic host changes induced by HPV appeared today in the International Journal of Cancer.

References

2023

  1. widhpv.jpg
    HPV‐induced host epigenetic reprogramming is lost upon progression to high‐grade cervical intraepithelial neoplasia
    Chiara Herzog*, Charlotte D. Vavourakis*, James E. Barrett, and 6 more authors
    International Journal of Cancer, 2023
    Abs HTML

    The impact of a pathogen on host disease can only be studied in samples covering the entire spectrum of pathogenesis. Persistent oncogenic Human Papilloma Virus (HPV) infection is the most common cause for cervical cancer. Here, we investigate HPV‐induced host epigenome‐wide changes prior to development of cytological abnormalities. Using cervical sample methylation array data from disease‐free women with or without an oncogenic HPV infection, we develop the WID (Women’s cancer risk identification)‐HPV, a signature reflective of changes in the healthy host epigenome related to high‐risk HPV strains (AUC=0.78, 95% CI: 0.72‐0.85, in non‐diseased women). Looking at HPV‐associated changes across disease development, HPV‐infected women with minor cytological alterations (cervical intraepithelial neoplasia grade 1/2, CIN1/2), but surprisingly not those with precancerous changes or invasive cervical cancer (CIN3+), show an increased WID‐HPV index, indicating the WID‐HPV may reflect a successful viral clearance response absent in progression to cancer. Further investigation revealed the WID‐HPV is positively associated with apoptosis (ρ=0.48; p<0.001) and negatively associated with epigenetic replicative age (ρ=‐0.43; p<0.001). Taken together, our data suggest the WID‐HPV captures a clearance response associated with apoptosis of HPV‐infected cells. This response may be dampened or lost with increased underlying replicative age of infected cells, resulting in progression to cancer. This article is protected by copyright. All rights reserved.




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