Biomarkers of Aging Consortium - Framework appears in Cell

August 31, 2023

2023 · biomarkers-of-aging-consortium ageing · papers

Our first manuscript of the Biomarkers of Aging Consortium, for which I had the pleasure to join the drafting team and am a co-first author on, appears today in Cell. We established a new framework and consensus for biomarkers of aging for the evaluation of longevity interventions.

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References

2023

Biomarkers of aging for the identification and evaluation of longevity interventions

Mahdi Moqri*, Chiara Herzog*, Jesse R. Poganik*, and 25 more authors

Cell, 2023

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With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.

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