Review on dietary restriction, senolysis, and ageing

2022

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   Dietary restriction in senolysis and prevention and treatment of disease

   Sepideh Aminzadeh-Gohari, Barbara Kofler, and Chiara Herzog

   Critical Reviews in Food Science and Nutrition, 2022

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   Aging represents a key risk factor for a plethora of diseases. Targeting detrimental processes which occur during aging, especially before onset of age-related disease, could provide drastic improvements in healthspan. There is increasing evidence that dietary restriction (DR), including caloric restriction, fasting, or fasting-mimicking diets, extend both lifespan and healthspan. This has sparked interest in the use of dietary regimens as a non-pharmacological means to slow aging and prevent disease. Here, we review the current evidence on the molecular mechanisms underlying DR-induced health improvements, including removal of senescent cells, metabolic reprogramming, and epigenetic rejuvenation.